Cytotoxic factors for modulating cell death
AssigneeThe Board of Trustees of the University of Illinois
InventorsAnanda M. Chakrabarty, Tapas K. Das Gupta, Vasu Punj, Olga Zaborina, Yoshinori Hiraoka, Tohru Yamada
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Abstract
Cytotoxic factors having use in modulating cell death, and their use in methods of treating necrosis or apoptosis-related conditions are disclosed. The invention also relates to methods for identifying active agents useful in treating conditions related to cell death or uncontrolled growth. The present inventors have found that different microorganisms produce different cytotoxic factor(s) having anticancer activity. The substantially pure cytotoxic factors can be used in a method of treating an infectious disease or a cancer.
Claims8
An isolated protein, that is a truncation of the amino acid sequence defined by SEQ ID NO:
- 2, wherein the protein binds to tumor suppressor protein p53, and wherein the protein is capable of inducing cell death in cancer cells.
Dependencies are inferred from the claim text.