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US 7,888,465 B2Granted
Methods for arbitrary peptide synthesis
AssigneeThe Invention Science Fund I, LLC
InventorsRoderick A. Hyde, Edward K. Y. Jung, Lowell L. Wood, Jr.
Life of this patent
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Abstract
Methods, apparatus, systems, computer programs and computing devices related to biologically assembling and/or synthesizing peptides and/or proteins are disclosed.
Claims54
A method comprising:
- determining, with one or more computing units, an order that two or more types of charged tRNA are to be co-localized sequentially with one or more ribosome-based assemblers on or in a fluidic device;
- and
- controlling the operation of the fluidic device with the one or more computing units so that the two or more types of charged tRNA are co-localized individually sequentially according to the determined order with the one or more ribosome-based assemblers.
A method of extra-cellular peptide synthesis comprising:
- determining, with one or more computing units, an order that two or more charged tRNA are to be co-localized sequentially with one or more ribosome-based assemblers on or in a fluidic device;
- and
- controlling the operation of the fluidic device with the one or more computing units so that the two or more charged tRNA are co-localized individually sequentially according to the determined order with the one or more ribosome-based assemblers in vitro.
A method comprising:
- determining an assembly order, with one or more computing units, that two or more types of charged tRNA are to be co-localized with one or more ribosome-based assemblers on or in a fluidic device;
- and
- controlling the operation of the fluidic device with the one or more computing units so that the two or more types of charged tRNA are co-localized individually sequentially according to the assembly order with the one or more ribosome-based assemblers based on the assembly order.
Dependencies are inferred from the claim text.