Diagnostic and therapeutic epitope, and transgenic plant
AssigneeIsis Innovation Limited
InventorsRobert Paul Anderson, Adrian Vivian Sinton Hill, Derek Parry Jewell
Life of this patent
Estimating the term…
Abstract
A food comprising a mutant gliadin protein that comprises at least one mutation in the epitope 62PQPQLPY68 (SEQ ID NO:6), wherein the mutation decreases the ability of the epitope to induce a T cell response, or a fragment of the mutant gliadin protein wherein the fragment is at least 15 amino acids long and comprises the mutated 62PQPQLPY68 (SEQ ID NO:6) is provided herein.
Claims15
A protein comprising:
- a) a mutant gliadin protein with a mutation in the epitope 62PQPQLPY68 (SEQ ID NO:6), wherein the glutamine residue at position 65 in A-gliadin, or in an equivalent position in other gliadins, is substituted to a histidine, tyrosine, tryptophan, lysine, proline, or arginine residue;
- or
- b) a fragment of the mutant protein of a), which fragment is at least 15 amino acids long and comprises the mutated PQPQLPY sequence.
A protein comprising a mutant gliadin protein with a mutation in the epitope 62PQPQLPY68 (SEQ ID NO:6), wherein the glutamine residue at position 65 in A-gliadin, or in an equivalent position in other gliadins, is substituted to a histidine, tyrosine, tryptophan, lysine, proline, or arginine residue.
A protein comprising a fragment of a mutant gliadin protein with a mutation in the epitope 62PQPQLPY68 (SEQ ID NO:6), wherein the glutamine residue at position 65 in A-gliadin, or in an equivalent position in other gliadins, is substituted to a histidine, tyrosine, tryptophan, lysine, proline, or arginine residue, which fragment is at least 15 amino acids long and comprises the mutated PQPQLPY sequence.
Dependencies are inferred from the claim text.