Ophthalmic and otorhinolaryngological device materials

A polymeric ophthalmic or otorhinolaryngological device material comprising

• a) 65 to 95% (w/w) of a monofunctional monomer of formula [1]:
• wherein
• B=—O(CH2)n—, —(OCH2CH2)n—;
• —NH(CH2)n—, or —NCH3(CH2)n—;
• R1=H, CH3, CH2CH3, or CH2OH;
• n=0-12;
• A=C6H5 or O(CH2)mC6H5, where the C6H5 group is optionally substituted with —(CH2)nH, —O(CH2)nH, —CH(CH3)2, —C6H5, —OC6H5, —CH2C6H5, F, Cl, Br, or I;
• and
• m=0-18;
• b) a difunctional cross-linking monomer of formula [2]:
• wherein
• R2, R3 independently=H, CH3, CH2CH3, or CH2OH;
• W, W′ independently=O(CH2)d, NH(CH2)d, NCH3(CH2)d, O(CH2)dC6H4, O(CH2CH2O)dCH2, O(CH2CH2CH2O)dCH2, O(CH2CH2CH2CH2O)dCH2, or nothing;
• J=(CH2)a, O(CH2CH2O)b, O, or nothing, provided that if W and W′=nothing, then J=O(CH2CH2O)b;
• d=0-12;
• a=1-12;
• and
• b=1-24;
• and
• c) 5 to 35% (w/w) of a hydrophilic side-chain macromer of formula [3a], [3b], [3c], [3d], or [3e]:
• wherein for formulas [3a], [3b], [3c], [3d], and [3e]
• R2, R3 independently=H, CH3, CH2CH3, or CH2OH;
• e, f independently=1-100;
• X, X1, X2 independently=O, NH—, N(CH3)—, N(CH2CH3)—, or N(C6H5)—;
• Y, Y1 independently=—H, —(CH2)pH, —CHC(CH3)2, —CH2CH2N(CH3)2, —CH2CH2N(CH2CH3)2, CH2CH2N(C6H5)2, —CH2CH(OH)CH2OH, CH2CH(OH)CH2OC6H5, (CH2CH2O)qCH3, (CH2CH2O)qH, (CH2CH2O)qC6H5, (CH2)tC6H5, (CH2)tOC6H5, or CH2CH2N(—C(O)CH2CH2CH2—),
• provided that Y≠Y1,
• and further provided that at least one of Y and Y1═CH2CH2N(CH3)2, —CH2CH2N(CH2CH3)2, CH2CH2N(C6H5)2, —CH2CH(OH)CH2OH, CH2CH(OH)CH2OC6H5, (CH2CH2O)qCH3, (CH2CH2O)qH, (CH2CH2O)qC6H5, or CH2CH2N(—C(O)CH2CH2CH2—);
• and the other of Y and Y1=—H, —(CH2)pH, —CHC(CH3)2, (CH2CH2O)qC6H5, (CH2)tC6H5, or (CH2)tOC6H5;
• p=1-18;
• q=1-230;
• t=0-6;
• R4═CH3OC(O)CH(CH3)—, CH3OC(O)C(CH3)2—, HOCH2CH2OC(O)C(CH3)2—, (CH2═C(R3)CO2CH2CH2OC(O)C(CH3)2—, CH3CH2OC(O)CH(CH3)—, CH3CH2OC(O)C(CH3)2—, CH3OC(O)CH(CH2CH3)—, CH3CH2OC(O)CH(CH2CH3)—, CH2═CHCH2OC(O)C(CH3)2—, CH3CH2OC(O)CH(CH2CH2CH3)—, CH3OC(O)CH(CH2CH2CH2CH3)—, [CH3OC(O)]2CH—, [CH3CH2OC(O)]2CH—, [CH3CH2OC(O)]2C(CH3)—, CH3CH2OC(O)CH(CH2CH2CH2CH3)—, (CH3)3COC(O)C(CH3)2—, CH3CH2OC(O)CH2CH3(CH2CH2CH2CH3)—, CH3CH2OC(O)CH(CH2CH2CH2CH2CH3)—, CH3CH2OC(O)CH(CH2CH2CH2CH2CH2CH3)—,
• provided that in the case of formula [3e], R4 is selected from the group consisting of (CH2═C(R3)CO2CH2CH2OC(O)C(CH3)2—, and CH2═CHCH2OC(O)C(CH3)2—,
• or
• g, g′ independently=1-12;
• and
• L=H, Cl, Br, —CH2C(O)CH3, CH2C(O)C(CH3)3, —CH2C(O)C6H5, —CH2C(O)C6H4OH, —CH2C(O)C6H4OCH3,
• or CH2CH═CH2.