Transdermal compositions
AssigneeMicrodermis Corporation
InventorGriscom Bettle, III
Life of this patent
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Abstract
The present invention is directed to transdermal compositions and the uses thereof. These compositions include at least one of the following components: a C1-C6 dialkyl, C12-C30 dialkyl quaternary ammonium salt, a C12-C30 fatty acid, a nitrogenous organic base, C12-C30 fatty alcohol, monoglyceride or the reaction products thereof.
Claims33
A composition comprising an antimicrobial effective amount of povidone iodine and tertiary amide of the formula:
- or pharmaceutically acceptable salts thereof wherein R4 is a fatty group of 11-29 carbon atoms;
- R5 and R6 are independently lower alkyl, aryl, aryl lower alkyl, or fatty group containing 11-29 carbon atoms or R7;
- R7 is
- R1—Ar—O—R2—O—R3—;
- R2 and R3 are independently lower alkylene groups containing 1-6 carbon atoms,
- R1 is a lower alkyl, and
- Ar is aryl.
A composition comprising an anti-microbial effective amount of povidone-iodine and a tertiary amide of the formula:
- or pharmaceutically acceptable salts thereof wherein
- R4 is a fatty group of 11-29 carbon atoms;
- R5 and R6 are independently aryl, aryl lower alkyl, or fatty group containing 11-29 carbon atoms containing one to eight carbon-carbon double bonds or R7;
- R7 is
- R1—Ar—O—R2—O—R3—;
- R2 and R3 are independently lower alkyl alkylene groups containing 1-6 carbon atoms;
- R1 is an alkyl group containing 1-15 carbon atoms;
- and
- Ar is aryl.
A composition comprising an anti-microbial effective amount of povidone-iodine and a tertiary amide hydrate formed from the process comprising heating a mixture of water, a quaternary surfactant, a fatty acid and an alkanolamine at a temperature greater than the melting point of said acid and less than 100° C. for sufficient time and under conditions effective to form a tertiary amide, cooling said tertiary amide to ambient temperature for sufficient time and under effective conditions for the pH of the water to stabilize and for said tertiary amide hydrate to form.
A composition comprising an anti-microbial effective amount of povidine-iodine and a therapeutically effective amount of an amide hydrate of a tertiary amide, where the tertiary amide has the formula:
- or pharmaceutically acceptable salts thereof wherein
- R4 is a fatty group of 11-29 carbon atoms;
- R5 and R6 are independently lower alkyl, aryl, aryl lower alkyl, or fatty group containing 11-29 carbon atoms or R7;
- R7 is
- R1—Ar—O—R2—O—R3—;
- R2 and R3 are independently alkylene groups containing 1-6 carbon atoms;
- R1 is an alkyl group containing 1-15 carbon atoms;
- and
- Ar is aryl.
Dependencies are inferred from the claim text.