Preparation of platinum(II) complexes
AssigneePlatco Technologies (Proprietary) Limited
InventorJan Gysbert Hermanus Du Preez
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Abstract
The invention relates to a method for the preparation of platinum (II) complexes, in particular dicarboxylatoplatinum (II) complexes containing a neutral bidentate ligand, such as oxaliplatin. The method includes the step of reacting a bis-dicarboxylatoplatinate (II) species with a suitable neutral bidentate ligand to form a neutral dicarboxylatoplatinum (II) complex and, if necessary, recrystallizing the product to form a pure dicarboxylatoplatinum (II) complex containing a neutral bidentate ligand. The invention also relates to a method for producing a bis-dicarboxylatoplatinate (II) species, and to new platinum (II) complexes that can be made by the method of the invention.
Claims10
A method for the preparation of oxaliplatin, the method comprising reacting a suitable platinum(II) species with trans-1-1,2-diaminocyclohexane, wherein the method does not utilize silver.
An oxaliplatin product containing no traces of silver, having a chemical purity of greater than 99.5%.
An oxaliplatin product containing no traces of silver, having an optical purity of greater than 99.98%.
A method of treating cancer in a patient, the method comprising administering a therapeutically effective amount of an oxaliplatin product containing no traces of silver to a patient in need thereof.
Dependencies are inferred from the claim text.