Airway alkalinization as therapy for airway diseases
OwnerJohn F. Hunt, Benjamin M. Gastoninventors
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Abstract
The present invention relates to a method of treating asthma by raising the pH of the airways of an individual. The effect can be mediated directly by administering a pharmaceutically acceptable basic solution or alternatively, the effect can be mediated by enhancing the activity of glutaminase.
Claims18
A method for enhancing the therapeutic efficacy of one or more agents, selected from the group consisting of corticosteroids, airway-smooth-muscle relaxants, and combinations thereof used in the treatment of one or more airway diseases selected from the group consisting of asthma, asthma exacerbations, smooth muscle constriction, airway inflammation, overproduction of mucus, human rhinovirus infection, common cold, allergic rhinitis, tuberculosis;
- cough, wheeze and airtrapping, said method comprising combining a non-toxic, alkaline composition with at least one said agent prior to bringing the resulting composition into contact with a patient's airways thereby alkalinizing said patient's airways.
A method comprising:
- combining a non-toxic, alkaline composition with at least one therapeutic agent selected from the group consisting of corticosteroids, airway-smooth-muscle relaxants, and combinations thereof;
- and
- bringing the resulting combination into contact with a patient's airways thereby alkalinizing said patient's airways.
A method for enhancing the therapeutic efficacy of an agent for treatment of an airway disease by raising the pH of an airway of a patient in need thereof, comprising:
- combining a non-toxic alkaline composition with at least one said airway disease agent, said agent selected from the group consisting of corticosteroids, airway-smooth-muscle relaxants, and combinations thereof, wherein the airway disease selected from the group consisting of asthma, asthma exacerbations, smooth muscle constriction, airway inflammation, overproduction of mucus, human rhinovirus infection, common cold, allergic rhinitis, tuberculosis, cough, wheeze and airtrapping;
- and
- bringing the composition and agent into contact with the airway of the patient to alkalinize the airway.
Dependencies are inferred from the claim text.