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US 7,888,379 B2Granted
Thiazole derivatives and use thereof
AssigneeMerck Serono SA
InventorsAnna Quattropani, David Covini, Vincent Pomel, Jerome Dorbais, Thomas Rueckle
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Abstract
The present invention is related to thiazole derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.
Claims11
A thiazole derivative according to Formula (I),
- wherein R1 is selected from cycloalkyl or acyl;
- R2 is selected from H, halogen, C1-C6-alkyl, C2-C6-alkenyl or C2-C6-alkynyl;
- R3 is selected from the following thienyl groups:
- R4 is selected from C2-C6-alkenyl, C2-C6-alkynyl, alkoxycarbonyl, sulfonyl or acyl;
- R5 and R6 are independently selected from H, C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or halogen;
- and isomers, enantiomers, diastereomers, racemates and pharmaceutically acceptable salts thereof.
3 more elements
Dependencies are inferred from the claim text.