Inhibitors of c-jun N-terminal kinases

A compound of the formula (I), or a pharmaceutically acceptable salt, or a combination thereof,

• wherein
• L1 is selected from the group consisting of —C(O)—NH—, and —NH—C(O)—;
• R1 is selected from the group consisting of alkenyl, alkenyloxyalkyl, alkoxyalkoxyalkyl, alkoxyalkyl, alkoxycarbonylalkyl, alkyl, alkylcarbonylalkyl, alkylsulfinylalkyl, alkylsulfonylalkyl, alkylthioalkyl, alkynyl, alkynylalkyl, alkynylalkoxyalkyl, aryl, arylalkenyl, arylalkenyloxyalkyl, arylalkoxyalkyl, arylalkyl, arylalkylsulfonylalkyl, arylalkylthioalkyl, arylcarbonylalkyl, aryloxyalkyl, arylthioalkyl, arylsulfinylalkyl, arylsulfonylalkyl, carboxyalkyl, cyanoalkyl, cycloakenyl, cycloalkenylalkoxyalkyl, cycloalkenylalkyl, cycloalkenylalkylthioalkyl, cycloalkenyloxy, cycloalkenyloxyalkyl, cycloalkenylsulfinylalkyl, cycloalkenylsulfonylalkyl, cycloalkenylthioalkyl, cycloalkyl, cycloalkylalkoxyalkyl, cycloalkylalkyl, cycloalkylalkylthioalkyl, cycloalkylcarbonylalkyl, cycloalkyloxyalkyl, cycloalkylsulfinylalkyl, cycloalkylsulfonylalkyl, cycloalkylthioalkyl, haloalkyl, heteroaryl, heteroarylalkoxyalkyl, heteroarylalkyl, heteroarylalkylsulfonylalkyl, heteroarylalkylthioalkyl, heteroarylcarbonylalkyl, heteroaryloxy, heteroaryloxyalkyl, heteroarylsulfinylalkyl, heteroarylsulfonylalkyl, heteroarylthioalkyl, heterocycle, heterocyclealkoxyalkyl, heterocycleakyl, heteroarylalkylsulfonylalkyl, heterocyclealkylthioalkyl, heterocyclecarbonylalkyl, heterocyclecarbonylalkenyl, heterocycleoxyalkyl, heterocyclesulfinylalkyl, heterocyclesulfonylalkyl, heterocyclethioalkyl, hydroxyalkyl, (RaRbN)alkyl, (RaRbN)carbonylalkenyl, (RaRbN)carbonylalkyl and (RaRbN)sulfonylalkyl;
• R2 is selected from the group consisting of hydrogen, alkyl, alkylcarbonyl, alkylsulfonyl, alkenyl, alkynyl, aryl, arylcarbonyl, arylsulfonyl, cycloalkyl, cycloalkylcarbonyl, cycloalkylsulfonyl, cycloalkenyl, cyano, haloalkyl, heteroaryl, heterocycle, nitro, formyl and alkynylalkenyl;
• R4 is selected from the group consisting of alkyl, alkylcarbonyl, alkylsulfonyl, alkenyl, alkynyl, aryl, arylcarbonyl, arylsulfonyl, cycloalkyl, cycloalkylcarbonyl, cycloalkylsulfonyl, cycloalkenyl, cyano, halo, haloalkyl, heteroaryl, heterocycle, nitro, formyl and alkynylalkenyl;
• R3 is selected from the group consisting of azido and RcRdN—;
• R5 is selected from the group consisting of alkenyl, alkoxy, alkoxyalkoxy, alkoxyalkoxyalkyl, alkoxyalkyl, alkyl, alkylcarbonylalkyl, alkylsulfonylalkyl, alkylthioalkyl, alkynyl, aryl, arylalkoxy, arylalkoxyalkyl, arylalkyl, aryloxy, aryloxyalkyl, arylthioalkyl, cyanoalkyl, cycloalkenyl, cycloalkenylalkoxy, cycloalkenylalkoxyalkyl, cycloalkenylalkyl, cycloalkyl, cycloalkylalkoxy, cycloalkylalkoxyalkyl, cycloalkylalkyl, cycloalkylalkylthioalkyl, cycloalkyloxy, cycloalkyloxyalkyl, cycloalkylthioalkyl, haloalkoxy, haloalkyl, heteroaryl, heteroarylalkoxy, heteroarylalkoxyalkyl, heteroarylalkyl, heteroarylalkylthioalkyl, heteroaryloxy, heteroaryloxyalkyl, heteroarylthioalkyl, heterocycle, heterocyclealkoxy, heterocyclealkoxyalkyl, heterocyclealkyl, heterocyclealkylthioalkyl, heterocycleoxy, heterocycleoxyalkyl, heterocyclethioalkyl, hydroxyalkyl, hydroxyalkoxy, ReRfN—, (ReRfN)alkyl, (ReRfN)alkoxy, -alkenyl-C(O)OH and —C(O)ReRfN,
• Ra and Rb are independently selected from the group consisting of hydrogen, alkoxyalkyl, alkoxyalkylcarbonyl, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkylthioalkyl, alkylthioalkylcarbonyl, alkylthiocarbonyl, aryl, arylalkoxyalkyl, arylalkyl, arylcarbonyl, cycloalkyl, cycloalkylalkyl, cycloalkylalkoxyalkyl, cycloalkylcarbonyl, formyl, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heterocycle, heterocyclealkyl, heterocyclealkoxyalkyl, heterocyclecarbonyl, (RgRhN)alkyl and (RgRhN)carbonyl;
• Rc and Rd are independently selected from the group consisting of hydrogen, alkyl, alkoxyalkyl, alkylcarbonyl, alkylsulfonyl, aryl, arylalkyl, arylalkylcarbonyl, arylalkylsulfonyl, arylcarbonyl, arylsulfonyl, cycloalkyl, cycloalkylcarbonyl, cycloalkylsulfonyl, formyl, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heteroarylsulfonyl, heterocycle, heterocyclealkyl, heterocyclecarbonyl and heterocyclesulfonyl;
• Re and Rf are independently selected from the group consisting of hydrogen, alkoxyalkyl, alkoxyalkylcarbonyl, alkoxycarbonyl, alkoxysulfonyl, alkyl, alkylcarbonyl, alkylsulfonyl, alkylthioalkyl, alkylthioalkylcarbonyl, alkylthiocarbonyl, aryl, arylalkoxyalkyl, arylalkyl, arylcarbonyl, cycloalkyl, cycloalkylalkoxyalkyl, cycloalkylalkyl, cycloalkylcarbonyl, formyl, heteroaryl, heteroarylalkoxyalkyl, heteroarylalkyl, heteroarylcarbonyl, heterocycle, heterocyclealkoxyalkyl, heterocyclealkyl, heterocyclecarbonyl, hydroxyalkyl, (RjRkN)alkyl and (RjRkN)carbonyl;
• Rg and Rh are independently selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, alkylcarbonyl, alkoxysulfonyl, alkylsulfonyl, aryl, arylalkyl, arylcarbonyl, cycloalkyl, cycloalkylalkyl, cycloalkylcarbonyl, formyl, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heterocycle, heterocyclealkyl and heterocyclecarbonyl;
• Rj and Rk are independently selected from the group consisting of hydrogen, alkoxycarbonyl, alkyl, alkylcarbonyl, alkylsulfonyl, aryl, arylalkyl, arylcarbonyl, cycloalkyl, cycloalkylalkyl, cycloalkylcarbonyl, formyl, heteroaryl, heteroarylalkyl, heteroarylcarbonyl, heterocycle, heterocyclealkyl and heterocyclecarbonyl.