Heterocyclic sulfonamides as modulators of cardiac sarcomeres

A compound represented by Formula I:

• wherein:
• R1, R2 and the nitrogen to which they are attached form a piperidine-1-yl ring, wherein the piperidin-1-yl ring is optionally substituted with one, two or three of the following groups:
• alkyl, halogen, hydroxy, alkoxy, alkylenedioxy, carboxy, acyloxy, alkoxycarbonyl, alkoxycarbonylamino, aminocarbonyl, cyano, acyl, oxo, nitro, amino, sulfanyl, sulfinyl, sulfonyl, aminosulfonyl, amidino, phenyl, benzyl, heteroaryl, heterocyclyl, aryloxy, arallkoxy, heteroaryloxy, and heteroaralkoxy;
• R3 is an aryl or heteroaryl group, which is optionally substituted with a halogen, lower alkoxy, aryl or heteroaryl group;
• R4 is halogen;
• R5 is hydrogen, halogen, hydroxy, or lower alkyl;
• and
• R6 and R7 are independently selected from hydrogen, halogen, hydroxy, and lower alkyl;
• or a pharmaceutically acceptable salt thereof.