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US 7,888,368 B2Granted
Treatment of drug-resistant tumors
AssigneeSigma-Tau Industrie Farmaceutiche Riunite S.p.A.
InventorsClaudio Pisano, Loredana Vesci
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Abstract
A subclass of camptothecin derivatives is disclosed to be useful for the preparation of a medicament for the treatment of drug-resistant tumors and/or for the administration to patients who show polymorphisms in the gene coding for DNA topoisomerase I.
Claims2
Method of treating a mammal suffering from a drug-resistant prostate carcinoma comprising administering a therapeutically effective amount of a compound of Formula I,
- where (R)2 is hydrogen or C1-C4 alkyl, to said mammal in need thereof, wherein said mammal shows polymorphism in the gene coding for DNA topoisomerase I.
Dependencies are inferred from the claim text.