Cyclohexyl or piperidinyl carboxamide antibiotic derivatives

A compound of formula I

• wherein
• R0 represents hydrogen or methyl;
• R1 represents hydrogen, halogen, (C1-C4)alkyl, (C1-C4)alkoxy, cyano or COOR2, R2 being (C1-C4)alkyl;
• one or two of U, V, W and X represent(s) N and each of the remaining represent CH, or, in the case of X, may also represent CRx, Rx being a halogen atom;
• either B represents N and A represents CH2CH2 or CH(OR3)CH2, or B represents CH or C(OR4) and A represents OCH2, CH2CH(OR5), CH(OR6)CH2, CH(OR7)CH(OR8), CH═CH or CH2CH2;
• each of R3, R4, R5, R6, R7 and R8 represents independently hydrogen, SO3H, PO3H2, CH2OPO3H2 or COR9, R9 being either CH2CH2COOH or such that R9—COOH is a naturally occurring amino acid or dimethylaminoglycine;
• D represents styryl, heteroarylvinyl, binuclear heteroaryl or a phenyl group which is substituted independently once or twice in the meta and/or para position(s) by a halogen, an alkyl group of one to three carbon atoms, an alkoxy group of one to three carbon atoms, a trifluoromethyl group or a trifluoromethoxy group;
• or a salt thereof.