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US 7,888,355 B2Granted
Compositions and methods for inhibiting growth and metastasis of melanoma
AssigneeBurnham Institute for Medical Research
InventorsZe′ev A. Ronai, Anindita Bhoumik, Nicholas D. P. Cosford, Russell Dahl
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Abstract
There are provided methods of inhibiting growth and metastasis of melanoma, methods of sensitizing melanoma cells to apoptosis, and methods of treating a subject having melanoma using acetyl isogambogic acid, celastrol, or a derivative thereof. There are further provided derivatives of celastrol and compositions comprising acetyl isogambogic acid, celastrol, or a derivative thereof.
Claims5
A compound having the structure I:
- wherein X is a moiety selected from a group consisting of a —O—CyH2y+1, —O—Z, —O—CH2—C(O)—R′, and NR″R′″, and wherein
- R′ is an alkyl;
- and
- each of R″ and R′″ is independently selected from a group consisting of H, an alkyl, an alkenyl, an alkadienyl, a substituted alkyl, benzyl, a substituted benzyl comprising a substituent attached directly to the ring, and a 3-methylenepyridyl, or N, R″ and R′″ taken together form a heterocycle selected from a group consisting of pyrrolidine, morpholine, and piperazine,
- Z is alkenyl or alkadienyl,
- y is selected from the group consisting of 2, 3, 5-10,
- with the further proviso that in each of the —O—CyH2y+1, R′, R″ and R′″, the alkyl, the alkenyl, where present, is straight-chained or branched.
4 more elements
Dependencies are inferred from the claim text.