Piperazine, [1,4]Diazepane, [1,4]Diazocane, and [1,5]Diazocane fused imidazo ring compounds

A compound of the Formula IV:

• wherein:
• X is a bond;
• X′ is —(CH2)2—;
• Y is selected from the group consisting of:
• a bond,
• —S(O)2—,
• —S(O)2—N(R8)—,
• —C(R6)—O—,
• —C(R6)—N(R8)—,
• —C(R6)—N(R8)—C(R6)—, and
• —C(R6)—N(R8)—S(O)2—;
• R1 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkenyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroaryienyl, and heterocyclyl wherein the alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, alkylthio, alkanoyl, alkanoyloxy, alkoxycarbonyl, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyano, aryl, aryloxy, arylthio, arylalkyleneoxy, heteroaryl, heteroaryloxy, heteroarylalkyleneoxy, heterocyclyl, amino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and in the case of alkyl, alkenyl, alkenyl, and heterocyclyl, oxo, and in the case of aryl, methylenedioxy;
• R is selected from the group consisting of:
• halogen,
• hydroxy,
• alkyl,
• alkenyl,
• haloalkyl,
• alkoxy,
• alkylthio, and
• N(R9)2;
• R3 is selected from the group consisting of:
• —Z—R4,
• —Z—X″—R4,
• —Z—X″—Y′—R4,
• —Z—X″—Y′—X″—Y′—R4, and
• —Z—X″—R5;
• m is 0 or 1;
• with the proviso that when m is 1, then n is 0 or 1;
• n is an integer from 0 to 4;
• X″ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, heteroarylene, and heterocyclylene wherein the alkylene, alkenylene, and alkynylene groups can be optionally interrupted or terminated by arylene, heteroarylene or heterocyclylene and optionally interrupted by one or more —O— groups;
• Y′ is selected from the group consisting of:
• —S(O)0-2—,
• —S(O)2—N(R8)—,
• —C(R6)—,
• —C(R6)—O—,
• —O—C(R6)—,
• —O—C(O)—O—,
• —N(R8)-Q-,
• —C(R6)—N(R8)—,
• —O—C(R6)—N(R8)—,
• —C(R6)—N(OR9)—,
• Z is a bond or —O—;
• R4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl wherein the alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyan, aryl, aryloxy, arylalkyleneoxy, heteroaryl, heteroaryloxy, heteroarylalkyleneoxy, heterocyclyl, amino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and in the case of alkyl, alkenyl, alkynyl, and heterocyclyl, oxo;
• R5 is selected from the group consisting of
• R6 is selected from the group consisting of ═O and ═S;
• R7 is C2-7 alkylene;
• R8 is selected from the group consisting of hydrogen, C1-10 alkyl, C2-10 alkenyl, C1-10 alkoxy-C1-10 alkylenyl, and aryl-C1-10 alkylenyl;
• R9 is selected from the group consisting of hydrogen and alkyl;
• R10 is C3-8 alkylene;
• R11 is selected from the group consisting of C1-6 alkyl and —Si(C1-6 alkyl)3;
• A is selected from the group consisting of —CH2—, —O—, —C(O)—, —S(O)0-2—, and N(R4)—;
• Q is selected from the group consisting of a bond, —C(R6)—, —C(R6)—C(R6)—, —S(O)2—, —C(R6)—N(R8)—W—, —S(O)2—N(R8)—, —C(R6)—O—, and —C(R6)—N(OR9);
• V is selected from the group consisting of —C(R6)—, —O—C(O)—, —N(R8)—C(R6)—, and —S(O)2—;
• W is selected from the group consisting of a bond, —C(O)—, and —S(O)2—;
• and
• a and b are independently integers from 1 to 6 with the proviso that a+b is ≦7;
• with the proviso that R, is not hydrogen or C1-4 alkyl when Y is a bond, and:
• n and m are both 0, or
• m is 0, n is 1, and R is selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, and halogen;
• or a pharmaceutically acceptable salt thereof.

A compound of the Formula IV:

• wherein:
• X is a bond;
• X′ is —(CH2)2—;
• Y is selected from the group consisting of:
• a bond,
• —S(O)2—,
• —S(O)2—N(R8)—,
• —C(R6)—,
• —C(R6)—N(R8)—,
• —C(R6)—N(R8)—C(R6)—, and
• —C(R6)—N(R8)—S(O)2—;
• R1 is selected from the group consisting of:
• hydrogen, alkyl, alkenyl, alkenyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl wherein the alkyl, alkenyl, alkenyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, alkylthio, alkanoyl, alkanoyloxy, alkoxycarbonyl, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyan, aryl, aryloxy, arylthio, arylalkyleneoxy, heteroaryl, heteroaryloxy, heteroarylalkyleneoxy, heterocyclyl, amino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and in the case of alkyl, alkenyl, alkenyl, and heterocyclyl, oxo, and in the case of aryl, methylenedioxy;
• further with the proviso that when Y is a bond, R1 is not hydrogen or C1-4 alkyl;
• R is selected from the group consisting of:
• halogen,
• hydroxy,
• alkyl,
• alkenyl,
• haloalkyl,
• alkoxy,
• alkylthio, and
• —N(R9)2;
• R3 is selected from the group consisting of:
• —Z—R4,
• —Z—X′—R4,
• —Z—X″—Y′—R4,
• —Z—X″—Y′—X″—Y′—R4, and
• —Z—X″—R5;
• m is 0 or 1;
• with the proviso that when m is 1, then n is 0 or 1;
• n is an integer from 0 to 4;
• X″ is selected from the group consisting of alkylene, alkenylene, alkynylene, arylene, heteroarylene, and heterocyclylene wherein the alkylene, alkenylene, and alkynylene groups can be optionally interrupted or terminated by arylene, heteroarylene or heterocyclylene and optionally interrupted by one or more —O— groups;
• Y is selected from the group consisting of:
• —S(O)0-2—,
• —S(O)2—N(R8)—,
• —C(R6)—,
• —C(R6)—O—,
• —O—C(R6)—,
• —O—C(O)—O—,
• —N(R8)-Q-,
• —C(R6)—N(R8)—,
• —O—C(R6)—N(R8)—,
• —C(R6)—N(OR9)—,
• Z is a bond or —O—;
• R4 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl wherein the alkyl, alkenyl, alkynyl, aryl, arylalkylenyl, aryloxyalkylenyl, alkylarylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, alkylheteroarylenyl, and heterocyclyl groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, hydroxyalkyl, haloalkyl, haloalkoxy, halogen, nitro, hydroxy, mercapto, cyan, aryl, aryloxy, arylalkyleneoxy, heteroaryl, heteroaryloxy, heteroarylalkyleneoxy, heterocyclyl, amino, alkylamino, dialkylamino, (dialkylamino)alkyleneoxy, and in the case of alkyl, alkenyl, alkynyl, and heterocyclyl, oxo;
• R5 is selected from the group consisting of
• R6 is selected from the group consisting of ═O and ═S;
• R7 is C2-7 alkylene;
• R8 is selected from the group consisting of hydrogen, C10 alkyl, C2-10 alkynyl, C1-10 alkoxy-C1-10 alkylenyl, and aryl-C1-10 alkylenyl;
• R9 is selected from the group consisting of hydrogen and alkyl;
• R10 is C3-8 alkylene;
• A is selected from the group consisting of —CH2—, —O—, —C(O)—, —S(O)0-2—, and N(R4)—;
• Q is selected from the group consisting of a bond, —C(R6)—, —C(R6)—C(R6)—, —S(O)2—, —C(R6)—N(R8)—W—, —S(O)2—N(R8)—, —C(R6)—O—, and —C(R6)—N(OR9);
• V is selected from the group consisting of —C(R6)—, —O—C(R6)—, —N(R8)—C(R6)—, and —S(O)2;
• W is selected from the group consisting of a bond, —C(O)—, and —S(O)2—;
• and
• a and b are independently integers from 1 to 6 with the proviso that a+b is ≦7;
• or a pharmaceutically acceptable salt thereof.