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US 7,888,338 B2Granted
7-(2-cyclohexylidene-ethylidene)-spiro[4.5]decanes
AssigneesK.U. Leuven Research & Development, Universiteit Gent
InventorsRoger Bouillon, Pierre De Clercq, Wim Schepens, Maurits Vandewalle, Annemieke Verstuyf
Life of this patent
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Abstract
The present invention relates to 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]-decanes, compositions which comprise said 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]-decanes, and methods for treating diseases, illnesses, and the like with said 7-(2-cyclohexylidene-ethylidene)-spiro[4.5]decanes.
Claims21
A compound having the formula:
- wherein R2a is hydrogen or C1-C20 substituted or unsubstituted linear, or branched hydrocarbyl, or C3 to C20 substituted or unsubstituted cyclic hydrocarbyl,
- wherein said substitution is chosen from:
- i) —NHCOR30;
- ii) —COR30;
- iii) —CO2R30;
- iv) —OCOR30;
- v) —C(═NH)NH2;
- vi) —NHC(═NH)NH2;
- vii) —N(R30)2;
- viii) —NHC6H5;
- ix) ═CHC6H5;
- x) —CON(R30)2;
- xi) —CONHNH2;
- xii) NHCN;
- xiii) —OCN;
- xiv) —CN;
- xv) halogen;
- xvi) —NHN(R30)2;
- xvii) —OR30;
- xviii) —NO2;
- xix) —CHmXn;
- wherein X is halogen, m is selected from 0, 1 and 2, n is selected from 0, 1, 2 and 3, and m+n=3;
- xx) —SO2R30;
- xxi) —OSO2R30;
- xxii) —OSO3R30;
- xxiii) —SO2N(R30)2;
- xxiv) ═O;
- xxv) ═NR30;
- xxvi) C1-C20 acyclic hydrocarbyl;
- xxvii) C3-C20 cyclic hydrocarbyl;
- xxviii) two hydrogen atoms on adjacent carbon atoms are substituted by a single oxygen atom, thereby forming an epoxy unit;
- and
- xxix) two hydrogen atoms on non-adjacent carbon atoms are substituted to form a C3-C20 cyclic hydrocarbyl;
- and wherein R30 is selected from the group consisting of hydrogen, C1-C10 linear or branched alkyl, C2-C10 linear or branched alkenyl, C2-C10 linear or branched alkynyl, C3-C20 heterocyclic, C5-C20 heteroaryl and C6-C14 aryl.
31 more elements
A compound having the formula:
- wherein R1b is chosen from:
- a) substituted or unsubstituted C1-C10 linear or branched alkyl;
- and
- b) substituted or unsubstituted C2-C20 linear or branched alkenyl;
- and
- i) —NHCOR30;
- ii) —COR30;
- iii) —CO2R30;
- iv) —OCOR30;
- v) —C(═NH)NH2;
- vi) —NHC(═NH)NH2;
- vii) —N(R30)2;
- viii) —NHC6H5;
- ix) ═CHC6H5;
- x) —CON(R30)2;
- xi) —CONHNH2;
- xii) —NHCN;
- xiii) —OCN;
- xiv) —CN;
- xv) halogen;
- xvi) —NHN(R30)2;
- xvii) —OR30;
- xviii) —NO2;
- xix) —CHmXn;
- wherein X is halogen, m+n=3;
- xx) —SO2R30;
- xxi) —OSO2R30;
- xxii) —OSO3R3;
- xxiii) —SO2N(R30)2;
- xxiv) ═O;
- and
- xxv) ═NR30;
- and
- wherein R30 is selected from the group consisting of hydrogen, C1-C10 linear or branched alkyl, C2-C10 linear or branched alkenyl, C2-C10 linear or branched alkynyl, and C6 or C10 aryl.
31 more elements
A compound having the formula:
- wherein R1a is chosen from:
- a) substituted or unsubstituted C1-C10 linear or branched alkyl;
- and
- b) substituted or unsubstituted C2-C20 linear or branched alkenyl;
- and
- i) —NHCOR30;
- ii) —COR30;
- iii) —CO2R30;
- iv) —OCOR30;
- v) —C(═NH)NH2;
- vi) —NHC(═NH)NH2;
- vii) —N(R30)2;
- viii) —NHC6H5;
- ix) ═CHC6H5;
- x) —CON(R30)2;
- xi) —CONHNH2;
- xii) —NHCN;
- xiii) —OCN;
- xiv) —CN;
- xv) halogen;
- xvi) —NHN(R30)2;
- xvii) —OR30;
- xviii) —NO2;
- xix) —CHmXn;
- wherein X is halogen, m+n=3;
- xx) —SO2R30;
- xxi) —OSO2R30;
- xxii) —OSO3R3;
- xxiii) —SO2N(R30)2;
- xxiv) ═O;
- and
- xxv) ═NR30;
- and
- wherein R3 is selected from the group consisting of hydrogen, C1-C10 linear or branched alkyl, C2-C10 linear or branched alkenyl, C2-C10 linear or branched alkynyl, and C6 or C10 aryl.
31 more elements
A compound having the formula:
- wherein R2b is chosen from:
- a) substituted or unsubstituted C1-C10 linear or branched alkyl;
- and
- b) substituted or unsubstituted C2-C20 linear or branched alkenyl;
- and
- i) —NHCOR30;
- ii) —COR30;
- iii) —CO2R30;
- iv) —OCOR30;
- v) —C(═NH)NH2;
- vi) —NHC(═NH)NH2;
- vii) —N(R30)2;
- viii) —NHC6H5;
- ix) ═CHC6H5;
- x) —CON(R30)2;
- xi) —CONHNH2;
- xii) —NHCN;
- xiii) —OCN;
- xiv) —CN;
- xv) halogen;
- xvi) —NHN(R30)2;
- xvii) —OR30;
- xviii) —NO2;
- xix) —CHmXn;
- wherein X is halogen, m+n 32 3;
- xx) —SO2R30;
- xxi) —OSO2R30;
- xxii) —SO3R30;
- xxiii) —SO2N(R30)2;
- xxiv) ═O;
- and
- xxv) ═NR30;
- and
- wherein R30 is selected from the group consisting of hydrogen, C1-C10 linear or branched alkyl, C2-C10 linear or branched alkenyl, C2-C10 linear or branched alkynyl, and C6 or C10 aryl.
31 more elements
Dependencies are inferred from the claim text.