Hydrazide-containing CFTR inhibitor compounds and uses thereof

A method for inhibiting cystic fibrosis transmembrane conductance regulator (CFTR) ion transport in a cell, the method comprising contacting the cell with a compound, wherein (a) the compound has the following formula (Ia):

• or a pharmaceutically acceptable salt or stereoisomer thereof,
• wherein X1 is hydrogen or a substituted or unsubstituted, saturated linear or branched alkyl;
• Y is hydrogen or substituted or unsubstituted, saturated linear or branched alkyl;
• R1 is unsubstituted phenyl,
• substituted phenyl wherein phenyl is substituted with one or more of hydroxy, alkyl, and halogen,
• substituted or unsubstituted anthracenyl, or
• substituted or unsubstituted naphthalenyl;
• R2 is unsubstituted phenyl,
• substituted phenyl, wherein phenyl is substituted with bromo or carboxy,
• di(hydroxy)phenyl,
• mono(halo)-mono(hydroxy)phenyl,
• mono(halo)-di(hydroxy)phenyl,
• mono(halo)-tri(hydroxy)phenyl,
• di(halo)-mono(hydroxy)phenyl,
• di(halo)-di(hydroxy)phenyl,
• di(halo)-tri(hydroxy)phenyl,
• mono(halo)-mono(hydroxy)-mono(alkoxy)phenyl,
• mono(halo)-di(hydroxy)-mono(alkoxy)phenyl,
• mono(halo)-mono(hydroxy)-di(alkoxy)phenyl,
• mono(halo)-di(hydroxy)-di(alkoxy)phenyl,
• di(halo)-mono(hydroxy)-mono(alkoxy)phenyl,
• di(halo)-di(hydroxy)-mono(alkoxy)phenyl,
• di(halo)-mono(hydroxy)-di(alkoxy)phenyl;
• and
• R3 is hydrogen or substituted or unsubstituted alkyl;
• or
• (b) the compound has the following formula (Ie):
• or a pharmaceutically acceptable salt or stereoisomer thereof,
• wherein Y″ is a substituted or unsubstituted, saturated linear or branched alkyl;
• or an amide or ether linker attached to a polar molecule, wherein the polar molecule is selected from a substituted or unsubstituted phenyl group, a polyoxyalkyl polyether, a polyethyleneimine, a disaccharide, a trisaccharide, a polyalkylimine, and a small amino dextran;
• R1 is unsubstituted or substituted phenyl, substituted or unsubstituted quinolinyl, substituted or unsubstituted anthracenyl, or substituted or unsubstituted naphthalenyl;
• R2 is unsubstituted or substituted phenyl;
• and
• R3 is hydrogen or substituted or unsubstituted alkyl, thereby inhibiting CFTR ion transport in the cell.