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US 7,888,327 B2Granted
Methods of using immunostimulatory nucleic acid molecules to treat allergic conditions
AssigneeUniversity of Iowa Research Foundation
InventorsArthur M. Krieg, Joel N. Kline
Life of this patent
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Abstract
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
Claims9
A method for treating an allergic condition, the method comprising administering to a subject in need of treatment of an allergic condition an immunostimulatory oligonucleotide 8 to 100 nucleotides long, comprising:
- 5′ X1X2CGX3X4 3′
- wherein the C is unmethylated and wherein X1, X2, X3, and X4 are nucleotides, wherein the oligonucleotide is administered without an allergen, in an effective amount to treat the allergic condition.
Dependencies are inferred from the claim text.