Antisense modulation of apolipoprotein B expression
AssigneeGenzyme Corporation
InventorsRosanne M. Crooke, Mark J. Graham
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for treatment of diseases associated with expression of apolipoprotein B are provided.
Claims20
An oligonucleotide 12 to 30 nucleobases in length, or a salt thereof, targeted to a nucleic acid molecule encoding apolipoprotein B, wherein the oligonucleotide is 100% complementary to SEQ ID NO:
- 3 and wherein the oligonucleotide comprises at least 8 consecutive nucleobases of SEQ ID NO:27.
Dependencies are inferred from the claim text.