Composition for treating a fibrotic disorder comprising an inhibitor of a BMP-1-like protein
AssigneeWisconsin Alumni Research Foundation
InventorsDaniel S Greenspan, Yue Zhang, Gaoxiang Ge
Life of this patent
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Abstract
α2-macroglobulin-related agents for treating or preventing a fibrotic disorder associated with fibrillogenesis are disclosed along with methods for using the agents, as well as methods for producing agents suited for use in the disclosed methods for treating or preventing a fibrotic disorder.
Claims9
An engineered α2-macroglobulin protein comprising an engineered bait region, the engineered bait region being a bone morphogenetic protein-1 bait region from a protein other than α2-macroglobulin that is cleaved by BMP-1, wherein the engineered α2-macroglobulin protein is characterized by an at least about 25-fold enhanced BMP-1 inhibitory effectiveness compared to a wild type α2-macroglobulin protein, and wherein the protein other than α2-macroglobulin is probiglycan.
Dependencies are inferred from the claim text.