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US 7,888,292 B2Granted
Nano-chem-FET based biosensors
AssigneeNanosys, Inc.
InventorsLarry Bock, R. Hugh Daniels, Stephen Empedocles, John C. Owicki
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Abstract
Methods of detecting a component of interest, a change in charge, a pH, a cellular response using nanosensors are provided. Nanosensors, including nanowires and nanowire arrays comprising functionalized and/or non-functionalized nanowires are provided. Nanosensors are used for detection in cellular fragmentation, multiple concentration analysis, glucose detection, and intracellular analysis.
Claims8
A method of detecting glucose, the method comprising:
- (a) providing one or more nanowires comprising a metal coating and glucose oxidase immobilized on the one or more nanowires or proximal thereto;
- (b) contacting the nanowires with a test solution;
- wherein any glucose present in the test solution is oxidized by the glucose oxidase resulting in a change in pH of the test solution, wherein the change in pH produces a signal in the nanowires;
- and,
- (c) detecting the signal, thereby detecting the glucose in the test solution.
2 more elements
Dependencies are inferred from the claim text.