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US 7,888,135 B2Granted
Diagnostic assay for Trypanosoma cruzi infection
AssigneeUniversity of Georgia Research Foundation, Inc.
InventorsRick L. Tarleton, Ronald D. Etheridge, Jr.
Life of this patent
Estimating the term…
Abstract
A sensitive, multicomponent diagnostic test for infection with T. cruzi, the causative agent of Chagas disease, including methods of making and methods of use. Also provided is a method for screening T. cruzi polypeptides to identify antigenic polypeptides for inclusion as components of the diagnostic test, as well as compositions containing antigenic T. cruzi polypeptides.
Claims10
An article comprising:
- a substrate;
- and
- a plurality of different individually addressable antigenic T. cruzi polypeptides selected from the polypeptides depicted in SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEQ ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, and SEQ ID NO:21, wherein said polypeptides are immobilized onto a surface of said substrate.
A kit for diagnosis of T. cruzi infection comprising:
- an article comprising a substrate and a plurality of different individually addressable antigenic T. cruzi polypeptides selected from the polypeptides depicted in SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, SEP ID NO:14, SEQ ID NO:15, SEQ ID NO:16, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, and SEQ ID NO:21, wherein said polypeptides are immobilized onto a surface of said substrate;
- and
- packaging materials and instructions for use.
Dependencies are inferred from the claim text.