Method of detecting auto-antibodies from patients suffering from rheumatoid arthritis, a peptide and an assay kit
AssigneeStichting voor de Technische Wetenschappen
InventorsWaltherus Jacobus Wilhelmus Van Venrooij, Jan Wouter Drijfhout, Martinus Adrianus Maria Van Boekel, Gerardus Jozef Maria Pruijn
Life of this patent
Estimating the term…
Abstract
The invention relates to method of detecting autoantibodies from patients suffering from rheumatoid arthritis. To this end, according to the invention, at least two peptide units are used of which at least one peptide unit comprises a part not derived from (pro)filaggrin, fibrin, fibrinogen, vimentin, cytokeratin 1 and cytokeratin 9, and which peptide unit comprises the motif XG, and a peptide unit comprising the motif XnonG, wherein X is a citrulline or an analogue thereof, and nonG is an amino acid other than glycine.
Claims3
A cyclic peptide that binds with antibodies obtained from patients with rheumatoid arthritis (RA), which peptide comprises an epitope selected from the group consisting of:
- 0002-27
- H Q K R G Cit G W S R A A
- (SEQ ID NO:
- 1)
- 0002-29
- H Q R R V Cit G W S R A A
- (SEQ ID NO:
- 2)
- 0002-31
- H Q R R T Cit G G S R A A
- (SEQ ID NO:
- 3)
- 0002-32
- H Q R K W Cit G A S R A A
- (SEQ ID NO:
- 4)
- 0002-36
- H Q F R F Cit G Cit S R
- (SEQ ID NO:
- 5)
- A A
- 0002-37
- H Q K W R Cit G R S Cit
- (SEQ ID NO:
- 6)
- A A
- and
- 0002-63
- H Q F R F Cit C W S R A A
- (SEQ ID NO:
- 7).
Dependencies are inferred from the claim text.