Back to results
US 7,888,127 B2Granted
Methods for reducing adduct formation for mass spectrometry analysis
AssigneeSequenom, Inc.
InventorThomas Becker
Life of this patent
Estimating the term…
Abstract
The invention provides a novel additive for improved analysis by mass spectrometry. More specifically, ascorbic acid has been found to reduce or eliminate the presence of adducts commonly present in mass spectra. The improved processes and compositions of the invention allow for increased accuracy, sensitivity and throughput for samples analyzed by mass spectrometry.
Claims14
A method of mass spectrometric analysis, comprising:
- (a) providing a composition comprising an analyte and an additive that includes ascorbic acid, or a salt, tautomer or analog thereof, and
- (b) analyzing the analyte by mass spectrometry, wherein the additive in the composition is in an amount that reduces the amount of an adduct formed under mass spectrometry conditions.
Dependencies are inferred from the claim text.