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US 7,888,125 B2Granted
Calibration of fluidic devices
AssigneeTheranos, Inc.
InventorsIan Gibbons, Chengwang Wang, Shaunak Roy, Elizabeth A. Holmes
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Abstract
The present invention provides methods of calibrating a fluidic device useful for detecting an analyte of interest in a bodily fluid. The invention also provides methods for assessing the reliability of an assay for an analyte in a bodily fluid with the use of a fluidic device. Another aspect of the invention is a method for performing a trend analysis on the concentration of an analyte in a subject using a fluidic device.
Claims6
A method of improving the accuracy of calibrating a fluidic system, comprising:
- a) providing a system for detecting an analyte in a bodily fluid from a subject comprising a fluidic device for providing said bodily fluid, said fluidic device having a calibration assembly and a reader assembly for detecting the presence of said analyte;
- b) measuring one or more parameters that are fitted to a calibration curve associated with said fluidic device;
- c) comparing said one or more parameters with predetermined parameters associated with said fluidic device;
- d) adjusting a signal output from the fluidic device by multiplying a ratio of said predetermined parameters to said one or more parameters, wherein the ratio is selected from the group consisting of:
- a ratio of maximum signal level during factory calibration to maximum signal level measured within the assay, and a ratio of minimun signal level during factory calibration to minimum signal level measured within an assay.
2 more elements
Dependencies are inferred from the claim text.