Global regulator of morphogenesis and pathogenicity in dimorphic fungi and uses thereof
AssigneeWisconsin Alumni Research Foundation
InventorsBruce S. Klein, Julie C. Nemecek, Marcel Wuethrich
Life of this patent
Estimating the term…
Abstract
A method of screening a compound for anti-fungal properties comprising the steps of exposing a test compound to a fungal histidine kinase, and determining whether kinase activity is inhibited, wherein inhibition of kinase activity indicates that the compound has anti-fungal properties is disclosed.
Claims3
A dimorphic fungus, wherein the fungus has a reduced histidine kinase expression and wherein the fungus has a reduced ability to morph into the virulent yeast form, wherein the kinase has been inactivated via RNAi, and wherein the kinase is Dimorphism Regulating Kinase 1 (DRK-1).
An isolated dimorphic fungus, wherein the fungus has a reduced histidine kinase expression and a reduced ability to morph into the virulent yeast form, and wherein the histidine kinase is Dimorphism Regulating Kinase 1 (DRK-1).
An isolated dimorphic fungus, wherein the fungus has a reduced histidine kinase expression and a reduced ability to morph into the virulent yeast form, and wherein the histidine kinase is the Dimorphism Regulating Kinase 1 (DRK-1) homologue found in C. immitis or H. capsulatum.
Dependencies are inferred from the claim text.