Uses of notch receptors, notch ligands, and notch modulators in methods related to metabolic diseases
AssigneeThe United States of America as represented by the Department of Health and Human Services
InventorsJosephine M. Egan, Máire E. Doyle
Life of this patent
Estimating the term…
Abstract
Disclosed are methods for identifying and isolating a precursor cell. Also, disclosed are methods of increasing insulin synthesis from a pancreatic B-cell. Further, disclosed are methods of improving pancreatic B-cell function. Still further, disclosed are methods of preventing or delaying the onset of a metabolic disease, methods of treating or preventing a metabolic disease in a subject, and to compositions for treating or preventing a metabolic disease in a subject in need of such treatment or prevention.
Claims20
A method for identifying a pancreatic precursor cell comprising contacting a pancreatic cell sample with a marker that selectively binds a Notch receptor and detecting the bound marker, the cell that binds the marker being a pancreatic precursor cell.
A method for isolating a pancreatic precursor cell from a pancreatic cell sample, comprising identifying a cell that comprises a Notch receptor and separating the identified cell from the pancreatic cell sample, the separated cell being a pancreatic precursor cell.
Dependencies are inferred from the claim text.