Liquid adenovirus formulations
AssigneeCrucell Holland B.V.
InventorsZheng Wu, Shuyuan Zhang
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Abstract
The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired properties that allow both lyophilized and liquid adenovirus formulations to be stored at 4° C. for up to 6 months and retain an infectivity between 60-100% of the starting infectivity.
Claims23
An adenovirus liquid formulation comprising adenovirus, a polyol, and a buffer, wherein the polyol is present in an amount to promote the maintenance of adenovirus infectivity.
An adenovirus liquid formulation comprising adenovirus, a polyol, a buffer, and a non-ionic detergent, wherein the polyol is present in an amount to promote the maintenance of adenovirus infectivity.
An adenovirus liquid formulation comprising adenovirus, a polyol, a buffer, and a salt selected from the group consisting of MgCl2, MnCl2, CaCl2, ZnCl2, NaCl, and KCl, wherein the polyol is present in an amount to promote the maintenance of adenovirus infectivity.
Dependencies are inferred from the claim text.