Subtilase variants
AssigneeNovozymes A/S
InventorsHenriette Draborg, Peter Kamp Hansen, Mads Eskelund Bjornvad, Mads Norregaard-Madsen, Mikael Mikkelsen
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Abstract
The present invention relates to novel subtilase variants exhibiting alterations relative to the parent subtilase in one or more properties including: Wash performance, thermal stability, storage stability or catalytic activity. The variants of the invention are suitable for use in e.g. cleaning or detergent compositions, such as laundry detergent compositions and dish wash compositions, including automatic dish wash compositions.
Claims13
An isolated variant of a parent subtilase comprising a set of amino acid substitutions corresponding to residues selected from the group consisting of:
- S9R+A13V+A15T+l35V+N62D+Q245F;
- and
- S9R+A15T+G20*+L21F+N62D+Q245N;
- wherein each amino acid position is numbered by correspondence to a position in the amino acid sequence of subtilisin BPN′ as set forth in SEQ ID NO:1.
An isolated variant of a parent subtilase comprising a set of amino acid substitutions corresponding to residues selected from the group consisting of:
- S9R+A15T+T22TG+N62D+V139L+Q245G;
- S9R+A15T+T22TG+N62D+V139L+Q245S;
- S9R+A15T+T22TG+N62D+V139L+Q245V;
- S9R+A15T+T22TL+N62D+I107V+V139L+Q245W;
- and
- S9R+A15T+T22TL+N62D+Q245W;
- wherein each amino acid position is numbered by correspondence to a position in the amino acid sequence of subtilisin BPN′ as set forth in SEQ ID NO:1.
Dependencies are inferred from the claim text.