Collagen-like protein CLAC, precursor thereof and genes encoding the same
AssigneeEisai R&D Management Co., Ltd.
InventorsTakeshi Iwatsubo, Tadafumi Hashimoto, Yasuo Nagai
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Abstract
A novel human collagen-like protein CLAC occurring in brain amyloid and its precursor CLAC-P; genes encoding the same; cDNA of mouse CLAC-P and its deduced amino acid sequence; antibodies specific to these proteins; and methods of diagnosing treating and preventing Alzheimer's disease by using the same.
Claims11
An expression vector containing a CLAC DNA comprising a nucleotide sequence of nucleotide 868 to nucleotide 2493 shown in SEQ ID NO:
- 1.
An expression vector containing a DNA encoding a CLAC protein comprising an amino acid sequence of amino acid 113 to amino acid 654 shown in SEQ ID NO. 2, said encoded protein having following properties:
- (a) accumulating in senile plaque amyloid component of Alzheimer's disease, and
- (b) having a function of promoting aggregation of Aβ.
An expression vector containing a CLAC-P DNA comprising a nucleotide sequence of nucleotide 532 to nucleotide 2493 shown in SEQ ID NO:
- 1.
An expression vector containing DNA encoding a CLAC-P protein comprising an amino acid sequence shown in SEQ ID NO:
- 2, said encoded protein functioning as an Aβ receptor on the cell surface.
A transformant deposited to the International Patent Organism Depositary, National Institute of Advanced Industrial Science and Technology under accession No. FERM BP-7438.
Dependencies are inferred from the claim text.