Method of stabilising or reactivating a creatinine sensor with a divalent manganese ion
AssigneeRadiometer Medical ApS
InventorsThomas Kjaer, Jens Østergaard, Tina Kristensen
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Abstract
A method is provided for stabilizing a creatinine sensor comprising creatininase as a bioactive molecule. The creatininase is stabilised by exposing it to a sufficient amount of a divalent manganese ion. This result may be obtained by exposing the sensor to a solution comprising the divalent manganese ion or by introducing a composition within the sensor providing sustained release of the divalent manganese ion.
Claims10
A method of stabilising or reactivating a creatinine sensor comprising creatininase as a bioactive molecule, comprising exposing the creatininase to an amount of a solution of a divalent manganese ion sufficient to increase the stability or to increase the activity of the sensor,
- wherein the solution comprises the divalent manganese ion in a concentration of in the range of about 2 to about 10 μM,
- wherein the creatininase is exposed to the solution of the divalent manganese ion for at least about 50% of the time, and
- wherein the sensor is arranged in a multi-sensor array.
Dependencies are inferred from the claim text.