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US 7,888,056 B2Granted
Method of forming a peptide-receptor complex with zsig33
AssigneeZymoGenetics, Inc.
InventorsPaul O. Sheppard, Darrell C. Conklin
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Abstract
The present invention relates to a method of forming a peptide-receptor complex with zsig33 polypeptides and their receptors as well as antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
Claims12
A method of identifying cells expressing a Growth Hormone Secretagogue Receptor (GHS-R) comprising;
- immobilizing a peptide comprising amino acid residues 24 to 37 of SEQ ID NO:2 on a solid support;
- contacting the peptide with cells expressing a receptor comprising amino acid residues 41 to 326 of SEQ ID NO:5;
- and
- detecting the binding of the GHS-R to the peptide wherein the peptide is labeled;
- whereby detection of the binding of the GHS-R to the peptide indicates that the cells express the GHS-R.
2 more elements
Dependencies are inferred from the claim text.