Loading patent…
AssigneeBiogen Idec MA Inc.
InventorsMichele Sanicola-Nadel, Kevin P. Williams, Susan Gail Schiffer, Paul Rayhorn
Estimating the term…
The invention provides Cripto blocking antibodies, or biologically functional fragments thereof, and uses thereof. Antibodies which bind Cripto and modulate Cripto signaling are provided. Antibodies which bind Cripto and block the interaction between Cripto and ALK4 are provided. Antibodies which bind Cripto and modulate tumor growth are also provided. Antibodies which bind Cripto, modulate signaling, and modulate tumor growth are also provided. Antibodies which bind Cripto, block the interaction between Cripto and ALK4 and modulate tumor growth are provided. The invention also provides methods of using these antibodies in therapeutic, diagnostic, and research applications.
A method for detecting a Cripto polypeptide, comprising contacting a composition with a monoclonal antibody that specifically binds to an epitope of Cripto comprised in the domain spanning amino acid residues from amino acid 46 to amino acid 62 of SEQ ID NO:
A method for detecting the expression of a Cripto polypeptide, comprising contacting a cell with a monoclonal antibody that specifically binds to an epitope of Cripto comprised in the domain spanning amino acid residues from amino acid 46 to amino acid 62 of SEQ ID NO:
A method for determining whether a cell or tissue expresses a Cripto polypeptide, comprising the step of contacting a cell or tissue isolated from a subject with a monoclonal antibody that specifically binds to an epitope comprised in the domain spanning amino acid residues from amino acid 46 to amino acid 62 of SEQ ID NO:
Dependencies are inferred from the claim text.