Back to results
US 7,888,045 B2Granted
Methods for identifying modulators of SF taste receptor signaling
AssigneeThe Regents of the University of California
InventorsCharles S. Zuker, Jon Adler, Nick Ryba, Ken Mueller, Mark Hoon
Life of this patent
Estimating the term…
Abstract
The invention provides isolated nucleic acid and amino acid sequences of taste cell specific G-protein coupled receptors, antibodies to such receptors, methods of detecting such nucleic acids and receptors, and methods of screening for modulators of taste cell specific G-protein coupled receptors.
Claims13
A method for identifying a compound that modulates taste signaling in taste cells, the method comprising the steps of:
- (i) contacting the compound with a taste transduction G-protein coupled receptor polypeptide, wherein the polypeptide is expressed in a taste cell, the polypeptide comprising greater than about 95% amino acid sequence identity to SEQ ID NO:41;
- and
- (ii) determining the functional effect of the compound upon the polypeptide, wherein, if said compound has a functional effect on said polypeptide, a compound that modulates taste signaling in taste cells is identified.
Dependencies are inferred from the claim text.