In vitro diagnostic method and kit for an Aspergillus infection
AssigneeInstitut Pasteur
InventorsAnne Beauvais, Jean-Paul Debeaupuis, Jean-Paul Latge, Sophie Paris, Jacqueline Sarfati
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Abstract
The present invention relates to a method for the in vitro diagnosis of an Aspergillus infection by determining in the serum or plasma sample of a subject the quantity of antibodies directed against a combination of at least two of the ribonuclease (RNU), catalase (CA) and dipeptidylpeptidase V (DPPV) Aspergillus antigens. The invention also relates to a diagnostic kit comprising said combination.
Claims31
A method for the in vitro diagnosis of an Aspergillus infection which comprises:
- a) incubating serum or plasma sample of a subject with Aspergillus antigens for the formation of immunocomplexes susceptible to be obtained between antibodies and the antigens, and
- b) determining the quantity of the antibodies directed against the Aspergillus antigens,
- wherein the Aspergillus antigens are selected from the group consisting of a combination of at least two the following antigens:
- the ribonuclease (RNU) antigen,
- the catalase (CA) antigen, and
- the dipeptidylpeptidase V (DPPV) antigen.
A diagnostic kit for determining in a serum or plasma sample a quantity of antibodies directed against Aspergillus antigens, comprising:
- (a) a combination consisting of at least two of the following isolated Aspergillus antigens:
- recombinant RNU antigen,
- recombinant CA antigen, and
- recombinant DPPV antigen.
Dependencies are inferred from the claim text.