Biomarkers
AssigneesKing's College London, Guys and St. Thomas's Nhs Foundation Trust
InventorsAsif Naeem Butt, Ramasamyiyer Swaminathan
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Abstract
The present invention provides circulating biomarkers for conditions associated with metabolic syndrome, including diabetes mellitus, hypertension and congestive heart failure. The biomarkers include plasma DNA, neuron-specific enolase, 11β-hydroxysteroid dehydrogenase, rhodopsin, retinoschisin, RPE65 and cardiac troponin T. Methods and kits for detecting these biomarkers in the prediction, monitoring and diagnosing of disease are provided, particularly for determining mRNA levels thereof in a subject's blood.
Claims8
A method for assessing susceptibility to a condition associated with metabolic syndrome in a subject, comprising determining a level of at least one mRNA in the subject's blood, wherein the at least one mRNA encodes RPE65 protein and the condition is at least one of diabetes mellitus, diabetic retinopathy, and diabetic mellitus without retinopathy, and determining the subject's susceptibility to said condition based on the level of said at least one mRNA.
Dependencies are inferred from the claim text.