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US 7,888,019 B2Granted
Genes involved estrogen metabolism
AssigneeGenomic Health, Inc.
InventorsMichael C. Kiefer, Joffre B. Baker, James Hackett
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Abstract
The invention concerns genes that have been identified as being involved in estrogen metabolism, and are useful as diagnostic, prognostic and/or predictive markers in cancer. In particular, the invention concerns genes the tumor expression levels of which are useful in the diagnosis of cancers associated with estrogen metabolism, and/or in the prognosis of clinical outcome and/or prediction of drug response of such cancers.
Claims8
A method of predicting the likelihood of a positive clinical outcome for a human subject diagnosed with breast cancer, comprising:
- assaying an expression level of (a) an RNA transcript of GSTM2, and (b) an RNA transcript of GSTM3 in a tumor sample obtained from said subject;
- normalizing the RNA levels of GSTM2 and GSTM3 against the RNA level of one or more reference genes to obtain normalized expression levels of GSTM2 and GSTM3;
- using the normalized expression levels of GSTM2 and GSTM3 to generate information comprising a prediction of the clinical outcome for said subject,
- wherein the normalized expression levels of GSTM2 and GSTM3 are positively correlated with a positive clinical outcome;
- and
- generating a report based on the information.
3 more elements
Dependencies are inferred from the claim text.