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US 7,888,010 B2Granted
Methods and compositions involving microRNA
AssigneeAsuragen, Inc.
InventorsDavid Brown, Kerri Keiger, Emmanuel Labourier, Jeffrey Shelton, Jaclyn Shingara
Life of this patent
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Abstract
The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.
Claims14
A method for identifying a patient as having a marker for lung cancer comprising
- a) analyzing mir-205 expression in a lung tissue sample from a patient suspected of having lung cancer;
- and
- b) identifying the patient as having a marker correlated with lung cancer when an increase in miR-205 of at least 50% in the lung tissue sample compared to a noncancerous lung tissue sample is determined or identifying the patient as not having the marker when the increase in miR-205 in the lung tissue sample fails to be determined.
A method for identifying a patient as having a marker correlated with lung cancer comprising:
- a) obtaining from a patient a lung tissue sample, wherein the patient is suspected of having lung cancer;
- b) identifying the patient as having a marker correlated with lung cancer if an increase of at least 50% in miR-205 expression in the lung tissue sample compared to a noncancerous lung tissue sample is determined or identifying the patient as not having the marker if the increase is not determined.
Dependencies are inferred from the claim text.