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US 7,887,845 B2Granted
Antiviral compositions
AssigneeJanssen Pharmaceutica NV
InventorsGeert Verreck, Lieven Baert
Life of this patent
Estimating the term…
Abstract
The present invention is concerned with pharmaceutical compositions of antiviral compounds which can be administered to a mammal, in particular a human, suffering from a viral infection. These compositions comprise particles obtainable by melt-extruding a mixture comprising one or more antiviral compounds and one or more appropriate water-soluble polymers and subsequently milling said melt-extruded mixture.
Claims66
A particle comprising a solid dispersion comprising
- (a) 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile, a N-oxide, a pharmaceutically acceptable addition salt, or a quaternary amine thereof
- and
- (b) one or more pharmaceutically acceptable water-soluble polymers.
A solid dispersion comprising
- (a) 4-[[4-amino-5-bromo-6-(4-cyano-2,6-dimethylphenyloxy)-2-pyrimidinyl]amino]benzonitrile;
- a N-oxide, a pharmaceutically acceptable addition salt, or a quaternary amine thereof;
- and
- (b) one or more pharmaceutically acceptable water-soluble polymers.
1 more element
Dependencies are inferred from the claim text.