Chronotherapeutic dosage forms and methods of treatment using chronotherapy
OwnerAnand R. Baichwal, Paul Woodcook +2inventors
InventorsAnand R. Baichwal, Paul Woodcook, Raymond Higgins, Jaclyn Cobb
Life of this patent
Estimating the term…
Abstract
A chronotherapeutic pharmaceutical formulation comprising a core containing an active agent (e.g., a drug) and a delayed release compression coating comprising a natural or synthetic gum applied onto the surface of the core.
Claims22
A delayed release oral solid dosage form, comprising a core comprising a therapeutically effective amount of a drug, and an agglomerated delayed release material compression coated onto said core, said delayed release material consisting essentially of an effective amount of xanthan gum and locust bean gum and an optional ingredient selected from the group consisting of a saccharide, an ionizable gel strength enhancing agent, a surfactant, a hydrophobic material, and any combinations thereof, said delayed release material providing a delay of the release of said drug from said dosage form until after a period of time from about 2 to about 18 hours after exposure of the dosage form to an aqueous solution.
A method of preparing a chronotherapeutic oral solid dosage form of a drug, comprising:
- preparing a core comprising a therapeutically effective amount of a drug and from about 5 to about 20% of an optional disintegrant, by weight of the core,
- preparing an agglomerated delayed release material consisting essentially of xanthan gum and locust bean gum and an optional ingredient selected from the group consisting of a saccharide, an ionizable gel strength enhancing agent, a surfactant, a hydrophobic material, and any combinations thereof,
- compression coating said agglomerated delayed release material onto said core, said compression coating delaying the release of said drug from said dosage form until after a period of time from about 2 to about 18 hours after exposure of the dosage form to an aqueous solution.
Dependencies are inferred from the claim text.