Drug delivery material
AssigneeShinji Takeoka
InventorsShinji Takeoka, Yousuke Okamura, Ippei Maekawa, Makoto Handa, Yasuo Ikeda
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Abstract
The present invention provides a drug delivery material, which is a conjugate of 1) a drug-carrying molecular assembly, 2) a linker and 3) a substance that recognizes activated platelet, injury site of blood vessel and/or inflammatory tissue, and capable of efficiently delivering a drug to a desired site, during which the drug under delivery does not affect sites other than a desired site (hence, low possibility of causing side effects), which releases the drug only at the desired site without requiring an external means and allows the drug to exhibit an effect.
Claims21
A drug delivery material which is a conjugate of 1) a drug encapsulating vesicle, 2) a linker and 3) a substance that recognizes an activated platelet and/or an injury site of blood vessel, wherein the drug is adenosine diphosphate and is encapsulated at a concentration of 1-6 mM in 10 mg/ml of a lipid constituting the vesicle, and wherein the substance that recognizes the activated platelet and/or the injury site of the blood vessel is selected from the group consisting of H12, GPIbα, GPIa/IIa, GPVI, MAC-I and fibrinogen.
Dependencies are inferred from the claim text.