Bone enhancing composite
AssigneeHepacore Ltd.
InventorAvner Yayon
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Abstract
A bone-enhancing composite material comprising synthetic apatite and at least one supplementary bioactive agent selected from a biocompatible polymer and an anti-resorptive agent added ab initio, methods of preparing said composite and uses thereof are provided. The physical and biological properties of the composite are controlled by the addition of specific supplementary bioactive agents as well as optional therapeutic agents. The composite may be used as a powder, a paste or an implant.
Claims32
A bone-enhancing composite comprising synthetic apatite and at least one of a biocompatible polymer and an anti-resorptive agent added ab initio, wherein the synthetic apatite comprises ionic calcium, phosphate, carbonate and at least one amino acid in monomeric or polymeric form.
A method for treating orthopedic, periodontal and craniofacial indications comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising synthetic apatite and at least one of a biocompatible polymer and an anti-resorptive agent added ab initio, wherein the synthetic apatite comprises ionic calcium, phosphate, carbonate and at least one amino acid in monomeric or polymeric form.
A method of preparing a bone enhancing composite comprising synthetic apatite and at least one of a biocompatible polymer and an anti-resorptive agent added ab initio, wherein the synthetic apatite comprises ionic calcium, phosphate, carbonate and at least one amino acid in monomeric or polymeric form, the method comprising the steps of:
- a) preparing a liquid mixture comprising ionic calcium, phosphate, at least one amino acid in either monomeric or polymeric form, carbonate, at least one of a biocompatible polymer and an anti-resorptive agent, optionally further comprising a therapeutic agent;
- b) subjecting said mixture to microwave irradiation;
- c) quenching said irradiated mixture;
- d) filtering said quenched mixture so as to separate between the filtrate and a cake;
- e) drying said cake;
- f) grinding said cake into a powder.
Dependencies are inferred from the claim text.