Peptides for stimulating an immune response against melanoma
AssigneesHealth Research, Inc., Hauptman-Woodward Medical Research Institute, Inc.
InventorsSoldano Ferrone, Chien-Chung Chang, Wei Luo, Xinhui Wang, Debashis Ghosh
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Abstract
Provided in the present invention are recombinant peptides and a method for using the peptides in stimulating an immune response against human high molecular weight-melanoma associated antigen (HMW-MAA). The peptides were designed from the identification of regions of structural and amino acid sequence homology between HMW-MAA and the mouse anti-idiotypic monoclonal antibody MK2-23. The method comprises the step of administering to an individual a peptide of the invention in an amount effective to elicit an immune response against HMW-MAA.
Claims18
A composition comprising one or more peptides selected from the group consisting of peptides having the sequence of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3, and wherein the peptide is capable of stimulating an antibody response against high molecular weight-melanoma associated antigen (HMW-MAA).
A method for stimulating an immune response against HMW-MAA in an individual comprising administering to the individual an amount of a composition effective to elicit an immune response against HMW-MAA wherein the composition comprises one or more peptides selected from the group consisting of peptides having the sequence of SEQ ID NO:1, SEQ ID NO:2 and SEQ ID NO:3.
Dependencies are inferred from the claim text.