Attenuated microorganisms for the treatment of infection
AssigneeEmergent Product Development UK Limited
InventorsRobert Graham Feldman, Gordon Dougan, Joseph David Santangelo, David William Holden, Jacqueline Elizabeth Shea, Zoe Hindle
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Abstract
The present invention pertains to a Salmonella microorganism having an attenuating mutation which disrupts the expression of a gene located within the Spi2 pathogenicity island, and an auxotrophic mutation. The microorganism therefore has a double mutation which helps prevent reactivity of the microorganism while maintaining the effectiveness of the microorganism to elicit an immune response. The present invention also pertains to vaccine compositions and methods for treating and preventing a Salmonella infection in a patient.
Claims37
A method of preventing or treating a Salmonella infection comprising administering to a patient a composition comprising Salmonella microorganisms, each microorganism comprising an attenuating mutation which disrupts expression of an ssaV gene and an attenuating mutation which disrupts expression of an aro gene.
A method for treating an infection comprising administering to a patient a composition comprising Salmonella microorganisms, each microorganism comprising:
- (i) an attenuating mutation which disrupts expression of an ssaV gene;
- (ii) an attenuating mutation which disrupts expression of an aro gene;
- and
- (iii) a gene encoding a heterologous antigen.
A method of inducing an immune response in a patient comprising administering to the patient a composition comprising Salmonella microorganisms, each microorganism comprising an attenuating mutation which disrupts expression of an ssaV gene and an attenuating mutation which disrupts expression of an aro gene.
Dependencies are inferred from the claim text.