Human Rgr oncogene and truncated transcripts thereof detected in T cell malignancies, antibodies to the encoded polypeptides and methods of use
AssigneeNew York University
InventorsAngel Pellicer, Peter Leonardi, Giorgio Inghirami
Life of this patent
Estimating the term…
Abstract
Naturally-occurring variants of human Rgr oncogene protein, in particular, abnormally truncated variants found in T cell malignancies, as well as the human Rgr protein are encompassed by the present invention. Also included are antibodies thereto and nucleic acid molecules encoding human Rgr protein and naturally-occurring variants thereof. The present invention further provides methods for diagnosing and treating T cell malignancies associated with abnormally truncated transcripts of human rgr oncogene and/or abnormal truncation of human Rgr protein.
Claims6
An isolated monoclonal antibody that binds to a polypeptide consisting of the amino acid sequence of SEQ ID NO:8.
An isolated molecule having the antigen binding portion of a monoclonal antibody which binds to an epitope of SEQ ID NO:
- 8, wherein the antigen binding portion comprises the Fab fragment, the Fab′ fragment, the F(ab′)2 fragment, or the variable domains of the heavy and light chains of the monoclonal antibody.
Dependencies are inferred from the claim text.