Methods for inhibiting VEGF-D
AssigneeVegenics Limited
InventorsBradley McColl, Megan E. Baldwin, Stephen A. Stacker, Marc G. Achen
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Abstract
Methods for activating endothelial growth factors VEGF-C or VEGF-D with plasmin, and methods of treatment comprising administering a pharmaceutical compositions comprising plasmin. Also disclosed are methods of screening for inhibitors of activation of the growth factors by plasmin, and method of treatment by blocking activation of VEGF-C/D activation by plasmin. Further disclosed are methods for screening for other proteases that activate VEGF-CD, and for inhibitors of such activation. The invention further includes inhibitors of plasmin activity and methods of treating patients in need thereof with said inhibitors.
Claims6
A method of blocking activation of VEGF-D comprising administering to a patient in need of inhibition of VEGF-D an anti-VEGF-D antibody or fragment thereof,
- wherein the antibody or fragment thereof binds VEGF-D that has a VEGF homology domain (VHD) and at least one of a C-terminal propeptide and an N-terminal propeptide,
- wherein the antibody or fragment thereof inhibits plasmin from proteolytically processing the VEGF-D to remove the at least one propeptide from the VHD.
Dependencies are inferred from the claim text.