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US 7,887,799 B2Granted
Antibodies to fibroblast growth factor-like polypeptides
AssigneeAmgen Inc.
InventorsArlen Thomason, Benxian Liu
Life of this patent
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Abstract
The present invention provides novel Fibroblast Growth Factor-like (FGF-like) polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing FGF-like polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with FGF-like polypeptides.
Claims12
An antibody or fragment thereof that specifically binds:
- (a) an amino acid sequence that is at least 95% identical to the amino acid sequence of either SEQ ID NO:
- 2 or SEQ ID NO:
- 5;
- (b) a fragment of the amino acid sequence of SEQ ID NO:
- 2 of at least 25 amino acid residues;
- (c) an amino acid sequence of SEQ ID NO:
- 2 or SEQ ID NO:
- 5 having a C- and/or N-terminal truncation, wherein the polypeptide is at least 25 amino acid residues;
- (d) an amino acid sequence that is encoded by a nucleotide sequence that is at least 95% identical to the nucleotide sequence of either SEQ ID NO:
- 1 or the DNA insert in ATCC Deposit No. PTA-626;
- (e) an amino acid sequence that is encoded by a nucleotide sequence encoding a polypeptide that is at least 95% identical to the polypeptide of either SEQ ID NO:
- 2 or SEQ ID NO:
- 5;
- or
- (f) an amino acid sequence that is encoded by a region of the nucleotide sequence of either SEQ ID NO:
- 1 or the DNA insert in ATCC Deposit No. PTA-626, encoding a polypeptide fragment of at least 25 amino acid residues.
13 more elements
A hybridoma that produces a monoclonal antibody that specifically binds:
- (a) an amino acid sequence that is at least 95% identical to the amino acid sequence of either SEQ ID NO:
- 2 or SEQ ID NO:
- 5;
- (b) a fragment of the amino acid sequence of SEQ ID NO:
- 2 of at least 25 amino acid residues;
- (c) an amino acid sequence of SEQ ID NO:
- 2 or SEQ ID NO:
- 5 having a C- and/or N-terminal truncation, wherein the polypeptide is at least 25 amino acid residues;
- (d) an amino acid sequence that is encoded by a nucleotide sequence that is at least 95% identical to the nucleotide sequence of either SEQ ID NO:
- 1 or the DNA insert in ATCC Deposit No. PTA-626;
- (e) an amino acid sequence that is encoded by a nucleotide sequence encoding a polypeptide that is at least 95% identical to the polypeptide of either SEQ ID NO:
- 2 or SEQ ID NO:
- 5;
- or
- (f) an amino acid sequence that is encoded by a region of the nucleotide sequence of either SEQ ID NO:
- 1 or the DNA insert in ATCC Deposit No. PTA-626, encoding a polypeptide fragment of at least 25 amino acid residues.
13 more elements
Dependencies are inferred from the claim text.