Methods of use of biodegradable injectable implants
AssigneesCrisoforo Peralta Casares, Daniel Leon de Lagarde
InventorsCrisoforo Peralta Casares, Daniel Leon de Lagarde
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Abstract
This invention is directed to the field of medical implants, and more specifically to biodegradable injectable implants and their methods of manufacture and use. The injectable implants disclosed herein comprise glycolic acid and bio-compatible/bio-absorbable polymeric particles containing a polymer of lactic acid. The particles are small enough to be injected through a needle but large enough to avoid engulfment by macrophages. The injectables of this invention may be in a pre-activated solid form or an activated form (e.g., injectable suspension or emulsion).
Claims20
A method for soft tissue augmentation comprising injecting a mammal at an injection site in need of such soft tissue augmentation a bulking agent suspended in a pharmaceutically acceptable carrier comprising glycolic acid monomer and polymeric particles comprising lactic acid repeat units, wherein the particles have a mean diameter of from about 40μ to about 80μ, and wherein the glycolic acid monomer is present in a concentration of from about 1.8 mcg to about 18.2 mcg glycolic acid monomer per 100 ml of the pharmaceutically acceptable carrier.
A method for treating facial lines comprising injecting a bulking agent at an injection site in a human, wherein the bulking agent is an injectable implant suspended in a pharmaceutically acceptable carrier comprising glycolic acid monomer and polymeric particles comprising lactic acid repeat units, wherein the particles have a mean diameter of from about 20μ to about 120μ, and wherein the glycolic acid monomer is present in a concentration of from about 1.8 mcg to about 18.2 mcg glycolic acid monomer per 100 ml of the pharmaceutically acceptable carrier.
A method for treating lipodystrophy comprising injecting a bulking agent at an injection site in a human, wherein the bulking agent suspended in a pharmaceutically acceptable carrier comprises glycolic acid monomer and polymeric particles comprising lactic acid repeat units, wherein the particles have a mean diameter of from about 20μ to about 120μ, and wherein the glycolic acid monomer is present in a concentration of from about 1.8 mcg to about 18.2 mcg glycolic acid monomer per 100 ml of the pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.