# US 7,887,491 B2 · Impedance based device for non-invasive measurement of blood pressure and ankle-brachial index > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 7,887,491 B2 - Document ID: US7887491B2 - Status: Granted - Kind: B2 - Application number: 11/875,355 - Filed: 2007-10-19 - Published: 2009-04-23 - Granted: 2011-02-15 - Earliest claimed: 2007-10-19 - Assignees: Smithmarks, Inc. - Inventors: Lloyd Marks; Michael Smith - Web page: https://patentgrep.com/patent/US7887491B2 ## CPC - A61B 5/022: by applying pressure to close blood vessels, e.g. against the skin; Ophthalmodynamometers - A61B 5/02141: {Details of apparatus construction, e.g. pump units or housings therefor, cuff pressurising systems, arrangements of fluid conduits or circuits (A61B5/02233, A61B5/0235 take precedence)} - A61B 5/6824: {Arm or wrist} - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) ## Abstract A device for non-invasive measurement of blood pressure includes a blood pressure cuff, a plethysmographic electrode for acquiring an impedance plethysmogram distal to the cuff and a processing device to inflate and deflate the cuff generate the impedance plethysmogram and to determine the systolic and diastolic blood pressures. The device can be used to measure systolic or diastolic blood pressure or both. It can also be used to take ankle-brachial measurements. An autocorrelation technique can be used to correct noise. ## Claims ### Claim 1 A method for non-invasively measuring blood pressure of a patient, the method comprising: (a) attaching a pressure cuff to an extremity of the patient; (b) attaching a plethysmographic device to the extremity at a distal location relative to the pressure cuff: (c) inflating and deflating the cuff; (d) taking a series of waveforms representing blood pulsations by using the plethysmographic device; (e) deriving, using a processor, a mathematical parameter from a combination of successive ones of the waveforms taken in step (d) and measuring the blood pressure from the mathematical parameter; and (f) outputting the blood pressure measured in step (e); wherein step (e) comprises multiplying corresponding points in groups of the waveforms to produce product waveforms and measuring the blood pressure from the product waveforms. ### Claim 2 (depends on 1) The method of claim 1, wherein the groups of the waveforms are groups of even numbers of the waveforms. ### Claim 3 (depends on 2) The method of claim 2, wherein the groups of the waveforms are groups of at least four of the waveforms. ### Claim 4 A method for non-invasively measuring blood pressure of a patient, the method comprising: (a) attaching a pressure cuff to an extremity of the patient; (b) attaching a plethysmographic device to the extremity at a distal location relative to the pressure cuff: (c) inflating and deflating the cuff; (d) taking a series of waveforms representing blood pulsations by using the plethysmographic device; (e) deriving, using a processor, a mathematical parameter from a combination of successive ones of the waveforms taken in step (d) and measuring the blood pressure from the mathematical parameter; and (f) outputting the blood pressure measured in step (e); wherein the blood pressure comprises systolic blood pressure; and wherein step (e) is performed twice, once with a first deflation rate and once with a second deflation rate which is slower than the first deflation rate. ### Claim 5 A method for non-invasively measuring blood pressure of a patient, the method comprising: (a) attaching a pressure cuff to an extremity of the patient; (b) attaching a plethysmographic device to the extremity at a distal location relative to the pressure cuff: (c) inflating and deflating the cuff; (d) taking a series of waveforms representing blood pulsations by using the plethysmographic device; (e) deriving, using a processor, a mathematical parameter from a combination of successive ones of the waveforms taken in step (d) and measuring the blood pressure from the mathematical parameter; and (f) outputting the blood pressure measured in step (e); wherein the blood pressure comprises diastolic blood pressure; and wherein step (e) comprises: (i) performing a point-by-point multiplication on the waveforms to obtain multiplied waveforms: and (ii) determining a maximum of the multiplied waveforms. ### Claim 6 A method for non-invasively measuring blood pressure of a patient, the method comprising: (a) attaching a pressure cuff to an extremity of the patient; (b) attaching a plethysmographic device to the extremity at a distal location relative to the pressure cuff: (c) inflating and deflating the cuff; (d) taking a series of waveforms representing blood pulsations by using the plethysmographic device; (e) deriving, using a processor, a mathematical parameter from a combination of successive ones of the waveforms taken in step (d) and measuring the blood pressure from the mathematical parameter; and (f) outputting the blood pressure measured in step (e); wherein the blood pressure comprises diastolic blood pressure; and wherein step (e) comprises: (i) performing a point-by-point multiplication on the waveforms to obtain multiplied waveforms; (ii) summing the multiplied waveforms to obtain a summed waveform; and (iii) determining a maximum of the summed waveform. ### Claim 7 (depends on 6) The method of claim 6, wherein step (e) is performed iteratively. ### Claim 8 A device for non-invasively measuring blood pressure of a patient, the device comprising: a pressure cuff for attachment to an extremity of the patient; a plethysmographic device for attachment to the extremity at a distal location relative to the pressure cuff; a processor, connected to the pressure cuff and the plethysmographic device, for inflating and deflating the cuff taking a series of waveforms representing blood pulsations by using the plethysmographic device, deriving a mathematical parameter from a combination of successive ones of the waveforms and measuring the blood pressure from the mathematical parameter; and an output for outputting the blood pressure measured by the processor; wherein the processor multiplies corresponding points in groups of the waveforms to produce product waveforms and measures the blood pressure from the product waveforms. ### Claim 9 (depends on 8) The device of claim 8, wherein the groups of the waveforms are groups of even numbers of the waveforms. ### Claim 10 (depends on 9) The device of claim 9, wherein the groups of the waveforms are groups of at least four of the waveforms. ### Claim 11 A device for non-invasively measuring blood pressure of a patient, the device comprising: a pressure cuff for attachment to an extremity of the patient; a plethysmographic device for attachment to the extremity at a distal location relative to the pressure cuff; a processor, connected to the pressure cuff and the plethysmographic device, for inflating and deflating the cuff taking a series of waveforms representing blood pulsations by using the plethysmographic device, deriving a mathematical parameter from a combination of successive ones of the waveforms and measuring the blood pressure from the mathematical parameter; and an output for outputting the blood pressure measured by the processor; wherein the blood pressure comprises systolic blood pressure; and wherein the processor is programmed to inflate and deflate the cuff twice, once with a first deflation rate and once with a second deflation rate which is slower than the first deflation rate. ### Claim 12 A device for non-invasively measuring blood pressure of a patient, the device comprising: a pressure cuff for attachment to an extremity of the patient; a plethysmographic device for attachment to the extremity at a distal location relative to the pressure cuff; a processor, connected to the pressure cuff and the plethysmographic device, for inflating and deflating the cuff taking a series of waveforms representing blood pulsations by using the plethysmographic device, deriving a mathematical parameter from a combination of successive ones of the waveforms and measuring the blood pressure from the mathematical parameter; and an output for outputting the blood pressure measured by the processor; wherein the blood pressure comprises diastolic blood pressure; and wherein the processor measures the diastolic blood pressure by: (i) performing a point-by-point multiplication on the waveforms to obtain multiplied waveforms; and (ii) determining a maximum of the multiplied waveforms. ### Claim 13 A device for non-invasively measuring blood pressure of a patient, the device comprising: a pressure cuff for attachment to an extremity of the patient; a plethysmographic device for attachment to the extremity at a distal location relative to the pressure cuff; a processor, connected to the pressure cuff and the plethysmographic device, for inflating and deflating the cuff taking a series of waveforms representing blood pulsations by using the plethysmographic device, deriving a mathematical parameter from a combination of successive ones of the waveforms and measuring the blood pressure from the mathematical parameter; and an output for outputting the blood pressure measured by the processor; wherein the blood pressure comprises diastolic blood pressure; and wherein the processor measures the diastolic blood pressure by: (i) performing a point-by-point multiplication on the waveforms to obtain multiplied waveforms; (ii) summing the multiplied waveforms to obtain a summed waveform; and (iii) determining a maximum of the summed waveform. ### Claim 14 (depends on 13) The device of claim 13, wherein the processor performs steps (i)-(iii) iteratively.