Modified DMO enzyme and methods of its use
AssigneeMonsanto Technology LLC
InventorsThomas E. Clemente, Razvan Dumitru, Paul C. C. Feng, Stanislaw Flasinski, Donald P. Weeks
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Abstract
The invention provides a modified variant of dicamba monooxygenase (DMO). The invention relates to the unexpected finding that cells expressing this DMO exhibit high levels of tolerance to the herbicide dicamba. Compositions comprising DMO-encoding nucleic acids and methods of use are provided.
Claims24
A nucleic acid molecule selected from the group consisting of:
- a) a nucleic acid molecule encoding the polypeptide of SEQ ID NO:1;
- b) a nucleic acid molecule comprising the sequence of SEQ ID NO:2;
- and
- c) a nucleic acid molecule encoding a polypeptide with at least 90% sequence identity to the polypeptide of SEQ ID NO:1, wherein the polypeptide has dicamba monooxygenase activity and comprises cysteine at a position corresponding to amino acid 112 of SEQ ID NO:1.
A polypeptide sequence comprising an amino acid sequence with at least 90% identity to SEQ ID NO:1, wherein the polypeptide has dicamba monooxygenase activity and comprises cysteine at a position corresponding to amino acid 112 of SEQ ID NO:1.
Dependencies are inferred from the claim text.