Salt of dimethylaminomethyl-phenyl-cyclohexane and crystalline forms thereof
AssigneeGruenenthal GmbH
InventorsMichael Gruss, Wolfgang Hell, Martin Szelagiewicz, Joerg Berghausen, Susan Margaret De Paul, Markus Von Raumer
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Abstract
Novel 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compounds corresponding to formula I and processes for preparing these compounds are provided. Pharmaceutical compositions including these compounds and methods of treating or alleviating pain with these compounds are also provided.
Claims18
A crystalline form of a 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compound corresponding to formula I
- and having
- a powder diffractogram comprising one or more of the following reflections:
- 9.38, 9.94 and 10.35, and
- a Raman spectrum comprising the following bands, in each case expressed in wavenumbers (cm-1):
- 118 (vs), 188 (w), 400 (w), 676 (vw), 2812 (w), 2879 (m).
A crystalline form of a 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compound corresponding to formula I
- and which exhibits an X-ray diffraction pattern as shown in FIG. 1 and a Raman spectrum as shown in FIG. 2.
A crystalline form of a 3-[2-(dimethylamino)methyl-(cyclohex-1-yl)]-phenol maleate compound corresponding to formula I
- and having:
- a powder diffractogram comprising one or more of the following reflections:
- 8.36, 14.5 and 14.83, and
- a Raman spectrum comprising the following bands, in each case expressed in wavenumbers (cm-1):
- 229 (m), 875 (m) and 2829 (m).
Dependencies are inferred from the claim text.